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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1389874Generated: October 26, 2026

3,4'-Dichloropropiophenone → 3-[4-(4-Bromo-1-naphthoyl)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochloride

https://huagongshe.com/reaction/1389874

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4'-DichloropropiophenoneHCID 77550—
Reactant4-ChlorobutyrophenoneHCID 253533—
Reactant2-Naphthyl 4-piperidyl ketone hydrochlorideHCID 20295547—
Reactant4-Bromo-1-naphthyl 4-piperidyl ketone hydrochlorideHCID 86737451—
Product3-[4-(4-Bromo-1-naphthoyl)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochlorideHCID 20295575—

Reaction Steps

When in the procedure of Example 19, 4-bromo-1-naphthyl 4-piperidyl ketone hydrochloride is substituted for 2-naphthyl 4-piperidyl ketone hydrochloride and 3-chloro-1-(4-chlorophenyl)-1-propanone substituted for 4-chloro-1-phenyl-1-butanone, 3-[4-(4-bromo-1-naphthoyl)-1-piperidyl]-1-(4-chlorophenyl)-1-propanone hydrochloride is produced.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04246268
Source datasetuspto-grants-1981_01
ORD IDord-c0eada3e546147aebd5556d648e51b98
Source noteuspto-grants-1981_01