HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → 6-[4-((4-Trifluoromethyl-2-naphthyl)methyl)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | 1-Hexanone, 6-bromo-1-(4-methoxyphenyl)- | HCID 10613105 | — |
| Reactant | 4-[(4-Trifluoromethyl-2-naphthyl)methyl]piperidine hydrochloride | HCID 20295630 | — |
| Reactant | 6-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride | HCID 70570161 | — |
| Product | 6-[4-((4-Trifluoromethyl-2-naphthyl)methyl)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone | HCID 20295538 | — |
Reaction Steps
When in the procedure of Example 25, 4-[(4-trifluoromethyl-2-naphthyl)methyl]piperidine hydrochloride is substituted for 6-chloro-2-naphthyl 4-piperidyl ketone hydrochloride and 6-bromo-1-(4-methoxyphenyl)-1-hexanone substituted for 4-chloro-1-(4-fluorophenyl)-1-butanone, 6-[4-((4-trifluoromethyl-2-naphthyl)methyl)-1-piperidyl]-1-(4-methoxyphenyl)-1-hexanone is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246268 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-4bdd4d37e6df42fd91ac43e2738a6091 |
| Source note | uspto-grants-1981_01 |