HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Fluorobenzoyl)propyl chloride → alpha-(4-Fluorophenyl)-4-[(6-chloro-2-naphthyl)hydroxymethyl]-1-piperidinebutanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Fluorobenzoyl)propyl chloride | HCID 19750 | — |
| Reactant | alpha-(3-Chloropropyl)-4-fluorobenzenemethanol | HCID 103540 | — |
| Reactant | alpha-(6-Chloro-2-naphthyl)-4-piperidinemethanol hydrochloride | HCID 20295621 | — |
| Reactant | 6-Chloro-2-naphthyl 4-piperidyl ketone | HCID 54320026 | — |
| Product | alpha-(4-Fluorophenyl)-4-[(6-chloro-2-naphthyl)hydroxymethyl]-1-piperidinebutanol | HCID 20295539 | — |
Reaction Steps
When in the procedure of Example 25, α-(6-chloro-2-naphthyl)-4-piperidinemethanol hydrochloride is substituted for 6-chloro-2-naphthyl 4-piperidyl ketone and 4-chloro-1-(4-fluorophenyl)butanol substituted for 4-chloro-1-(4-fluorophenyl)-1-butanone, α-(4-fluorophenyl)-4-[(6-chloro-2-naphthyl)hydroxymethyl]-1-piperidinebutanol is produced.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246268 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-6d7f03928ce248f792c70d25e6feab49 |
| Source note | uspto-grants-1981_01 |