HCID 88764022, compound → HCID 13193157, compound

Participants

Reaction Steps

Zinc powder (4.0 g.) was added portionwise to a stirred solution of 2,2,2-trichloroethyl 7-(2-phenylacetamido)-3-tosyloxy-3-cephem-4-carboxylate (0.8 g.) in formic acid (16 ml.) over 3 minutes under ice-cooling. The mixture was stirred at the same temperature for 5 minutes and then filtered. The remaining zinc powder was washed with ethyl acetate. The filtrate and washings were combined together, washed three times with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and then evaporated to dryness in vacuo. The residue was pulverized by trituration with diisopropyl ether and the precipitates were collected by filtration to give 7-(2-phenylacetamido)-3-cephem-4-carboxylic acid (0.32 g.), Yield 78.1%.

Provenance & Evidence