HCID 88389564, compound → HCID 13193157, compound

Participants

Reaction Steps

Zinc powder (2.0 g.) was added portionwise to a stirred solution of 4-nitrobenzyl 7-(2-phenylacetamido)-3-tosyloxy-3-cephem-4-carboxylate (2.0 g.) in 90% formic acid (40 ml.) over 6 minutes under ice-cooling. The mixture was stirred at room temperature for an hour and then filtered. The remaining insoluble substances were washed with ethyl acetate. The filtrate and the washings were combined together and evaporated in vacuo. The residue was dissolved in ethyl acetate, washed with water, diluted hydrochloric acid and water in turn, dried over magnesium sulfate and then evaporated to dryness in vacuo. The oily residue was pulverized by trituration with diisopropyl ether and the solidified precipitates were collected by filtration to give 7-(2-phenylacetamido)-3-cephem-4-carboxylic acid (0.73 g.), Yield 71.5%.

Provenance & Evidence