HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178508796, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thiomorpholine hydrochloride | HCID 3014410 | — |
| Reactant | methyl N-(3,5-diamino-6-chloropyrazine-2-carbonyl)carbamimidothioate;hydroiodide | HCID 140329753 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178508796 | HCID 178508796 | — |
Reaction Steps
Thiomorpholine hydrochloride (2.10 g., 0.015 mole), triethylamine (2.1 ml., 0.015 mole), and 1-(3,5-diamino-6-chloropyrazinoyl)-2-methyl-2-thiopseudourea hydroiodide (1.94 g., 0.005 mole) are heated in tetrahydrofuran (50 ml.) at reflux for 4 hrs. The reaction mixture is added to ice-water to precipitate 590 mg. of 3,5-diamino-6-chloro-N-[(4-thiomorpholinyl)aminomethylene]-2-pyrazinecarboxamide which melts at 234°-6° C. after reprecipitation from dilute hydrochloric acid with sodium hydroxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246406 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-fdf0c11b78fb4a60b0813aea7d68dda8 |
| Source note | uspto-grants-1981_01 |