Hydrochloric Acid → 5-(3-Chlorosulfonylbenzenesulfonamido)-1-naphthol

Participants

Reaction Steps

To a stirred mixture of 2.1 g of 5-amino-1-naphthol (1/2 H2SO4 salt), 4.2 g of benzene-1,3-disulfonyl chloride, 10 ml of acetonitrile and 30 ml of methanol was added portionwise 3.4 g of sodium hydrogen carbonate at a temperature of 0° to 5° C. The mixture was stirred for 1 hour at 0° to 5° C. and poured into 300 ml of a 3% hydrochloric acid aqueous solution. The precipitated crude product was collected by filtration and recrystallized from benzene-ethyl acetate (1:1 by volume) to produce 2.9 g of the title compound.

Provenance & Evidence