Sodium Hydroxide → 4-Amino-6-[(2,2-dimethoxyethyl)amino]-1,3,5-triazin-2(5H)-one

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Reaction Steps

A suspension of 2-amino-4-chloro-6-hydroxy-s-triazine (II) 15.0 g, 0.102 mol) in 250 mL of water was treated with sodium hydroxide (4.095 g, 0.102 mol), and the mixture was stirred to obtain a clear solution which was treated with aminoacetaldehyde dimethyl acetal (12.9 g, 0.12 mol). The mixture was heated under gentle reflux for 2.5 h. with stirring and then cooled to room temperature. The crystalline solid that separated was collected and washed with cold water (2×25 mL). Recrystallization from a large excess of water gave the compound as needles: 15.0 g (68.0%); mp 285° C. dec. Anal. (C7H13N5O3, 215.21) C, H, N.

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