Acetic Acid → HCID 20296017, compound

Participants

Reaction Steps

To a stirred mixture of 17.4 parts of methyl 2-aminobenzoate 18.5 parts of 4-bromobenzaldehyde in 200 parts of glacial acetic acid is added dropwise a solution of 8.15 parts of potassium cyanide in 15 parts of water, while keeping the temperature below 16° C. Upon completion, stirring is continued for 19 hours at room temperature. The precipitated product is filtered off, washed with 2,2'-oxybispropane and dried in vacuo, yielding 25 parts of methyl 2-{[(4-bromophenyl)cyanomethyl]amino}benzoate; mp. 111.5° C.

Provenance & Evidence