((4-Chlorophenyl)amino)(2,6-dichlorophenyl)acetonitrile → 2-[(4-Chlorophenyl)amino]-2-(2,6-dichlorophenyl)acetamide

Participants

Reaction Steps

50 Parts of 2,6-dichloro-α-[(4-chlorophenyl)amino]benzeneacetonitrile are added portionwise to 270 parts of sulfuric acid/water (10:1 by volume) and the whole is stirred overnight at room temperature. The reaction mixture is poured onto 2000 parts of ice-water. The precipitated product is filtered off, washed on the filter successively with water and 2-propanol and recrystallized from 560 parts of 2-propanol at -20° C., yielding 43.1 parts of 2,6-dichloro-α-[(4-chlorophenyl)amino]benzeneacetamide; mp. 178° C.

Provenance & Evidence