反应详情

To 360 parts of concentrated sulfuric acid are added portionwise 30 parts of 2,6-dichloro-α-[(2-naphthalenyl)amino]benzeneacetonitrile and the whole is stirred till all solid enters solution. The reaction solution is allowed to stand overnight at room temperature and then poured onto 1000 parts of crushed ice. The precipitated product is filtered off and extracted with 1500 parts of chloroform. The organic phase is washed with water, dried, filtered and evaporated. The oily residue solidifies on triturating in 2-propanol. The solid product is filtered off and crystallized from 200 parts of 2-propanol at 0° C., yielding 11.3 parts of 2,6-dichloro-α-[(2-naphthalenyl)amino]benzeneacetamide; mp. 157.9° C.

1. additionpoured onto 1000 parts of crushed ice
2. filtrationThe precipitated product is filtered off
3. extractionextracted with 1500 parts of chloroform
4. washThe organic phase is washed with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. customon triturating in 2-propanol
9. filtrationThe solid product is filtered off
10. customcrystallized from 200 parts of 2-propanol at 0° C.