Ammonium Chloride → HCID 20296004, compound

Participants

Reaction Steps

To a stirred and refluxed mixture of 37.5 parts of 2,6-dichloro-α-[(4-chlorophenyl)amino]-3-nitrobenzeneacetamide, 500 parts of an ammonium chloride solution 1 N and 800 parts of methylbenzene are added 28 parts of iron powder. Upon completion, stirring at reflux is continued for 50 minutes. The reaction mixture is filtered and the crystallized product is filtered off from the filtrate. It is boiled in 1000 parts of methylbenzene: one part dissolves, but crystallized again upon cooling to room temperature. It is filtered off and dried, yielding 7.1 parts of 3-amino-2,6-dichloro-α-[(4-chlorophenyl)amino]benzeneacetamide; mp. 231.8° C.

Provenance & Evidence