Acetic Acid → HCID 20295989, compound

Participants

Reaction Steps

A mixture of 43 parts of methyl 5-(α-carbamoyl-o-chlorobenzylamino)-2,4-dichlorobenzoate, 400 parts of a hydrochloric acid solution and 200 parts of glacial acetic acid is stirred and refluxed for 70 hours. The reaction mixture is cooled and the precipitated product is filtered off. It is washed on the filter with fresh water and then dissolved in ether. The ethereal solution is shaken with water and with alkaline water. The aqueous phase is separated, acidified with a hydrochloric acid solution and the product is extracted with ether. The latter is washed twice with water, dried, filtered and evaporated, yielding 34.1 parts of N-(5-carboxy-2,4-dichlorophenyl)-2-(o-chlorophenyl)glycine as a solid residue; mp. 210° C.

Provenance & Evidence