反应详情

A mixture of 12.7 parts of 2-(2,6-dichlorophenyl)-2-(2-naphthylamino) acetamide and 250 parts of potassium hydroxide/ethanol 1 N is stirred and refluxed for 48 hours. The reaction mixture is evaporated. The oily residue is dissolved in 400 parts of water and the solution is acidified with concentrated hydrochloric acid solution. The sticky product is extracted with 1,1'-oxybisethane. The extract is washed twice with water, dried and evaporated. The oily residue is triturated three times in petroleumether. The solid product is filtered off and recrystallized from 50 parts of glacial acetic acid. The product is washed with petroleumether, dried and dissolved in 80 parts of 1,1'-oxybisethane. The solution is stirred with activated charcoal, filtered and the filtrate is evaporated. The oily residue solidifies on triturating in 2-propanol and petroleumether. The solid is filtered off and dried, yielding 1.6 parts of 2-(2,6-dichlorophenyl)-N-(2-naphthyl)glycine; mp. 171.7° C.

1. temperaturerefluxed for 48 hours
2. customThe reaction mixture is evaporated
3. dissolutionThe oily residue is dissolved in 400 parts of water
4. extractionThe sticky product is extracted with 1,1'-oxybisethane
5. washThe extract is washed twice with water
6. customdried
7. customevaporated
8. customThe oily residue is triturated three times in petroleumether
9. filtrationThe solid product is filtered off
10. customrecrystallized from 50 parts of glacial acetic acid
11. washThe product is washed with petroleumether
12. customdried
13. dissolutiondissolved in 80 parts of 1,1'-oxybisethane
14. stirringThe solution is stirred with activated charcoal
15. filtrationfiltered
16. customthe filtrate is evaporated
17. customon triturating in 2-propanol
18. filtrationThe solid is filtered off
19. customdried