Ethanol → HCID 20296030, compound

Participants

Reaction Steps

To a stirred and refluxed solution of 40 parts of ethanol, 25 parts of water and 2 parts of sodium hydroxide are added 5 parts of ethyl 2-(o-methoxyphenyl)-N-(2,4,5-trichlorophenyl)glycine and stirring at reflux temperature is continued for 4 hours. The reaction mixture is evaporated. The residue is dissolved in 250 parts of water. The solution is shaken with 80 parts of ether and the aqueous phase is acidified with concentrated hydrochloric acid solution. The product is extracted twice with 80 parts of ether. The combined extracts are dried and evaporated. The solid residue is crystallized from 50 parts of glacial acetic acid at room temperature, yielding 3.2 parts of 2-(o-methoxyphenyl)-N-(2,4,5-trichlorophenyl)glycine; mp. 188.3° C.

Provenance & Evidence