Chloroacetyl chloride → HCID 54084673, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3 parts of ethyl α-[(4-bromophenyl)amino]-2,3,6-trichlorobenzeneacetate and 4.5 parts of 2-chloroacetyl chloride is stirred for 4 hours at 80° C. The mixture is taken up twice in methylbenzene and the latter is evaporated each time. The oily residue solidifies on triturating in petroleumether. The latter is decanted and the residue is crystallized from 2,2'-oxybispropane. The product is filtered off and dried, yielding a first fraction of 1.7 parts of ethyl α-[(4-bromophenyl) (2-chloroacetyl)-amino]-2,3,6-trichlorobenzeneacetate; mp. 140.8° C. The mother liquor is concentrated and a second fraction of 1.2 parts of ethyl α-[(4-bromophenyl) (2-chloroacetyl)amino]-2,3,6-trichlorobenzeneacetate is filtered off.

Provenance & Evidence