HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → Fenbufen EP Impurity D
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanone | HCID 20294315 | — |
| Reactant | 4-(4'-Methoxy-biphenyl-4-yl)-4-oxo-butyric acid | HCID 23005238 | — |
| Product | Fenbufen EP Impurity D | HCID 13930818 | — |
Reaction Steps
The compound Dihydro-5-(4'-hydroxy-4-biphenylyl)-2(3H)-furanone may be prepared by treating 4'-methoxy-γ-oxo-4-biphenylbutyric acid with hydrogen bromide in acid to produce 4'-hydroxy-γ-oxo-4-biphenylbutyric acid. This in turn is treated with sodium borohydride as described above and then purified with organic solvents to produce the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04247466 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-c96a0bb6a0a24592a8b775bb9406c92a |
| Source note | uspto-grants-1981_01 |