Acetic Anhydride → N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

HRID 1390006Notes

Reaction equation

HRID 1390006 reaction equation
[CH3:1][C:2]1[N:3]([NH:8][C:9]2[N:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[C:21](OC(=O)C)(=[O:23])[CH3:22]>N1C=CC=CC=1>[C:21]([N:8]([N:3]1[C:4]([CH3:7])=[CH:5][CH:6]=[C:2]1[CH3:1])[C:9]1[N:10]=[N:11][C:12]([N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)=[CH:13][CH:14]=1)(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 711434-(6-((2,5-Dimethylpyrrol-1-yl)amino)-3-pyridazinyl)morpholine

Product 1

HCID 23276131N(2,5-DIME-PYRROL-1-YL)-6-($-MORPHOL)-3-PYRIDAZ-

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 6 g (22 m mol) of N-(2,5-dimethyl-1H-pyrrol-yl)-6-morpholino-3-pyridazineamine, 30 ml of acetic anhydride, and 6 ml of pyridine is heated for one hour at 110° C. The reaction mixture is evaporated to dryness under vacuum and the oily residue is dissolved in 150 ml of ethyl acetate. The organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate and then with 50 ml of water.

Workup

  1. customThe reaction mixture is evaporated to dryness under vacuum
  2. dissolutionthe oily residue is dissolved in 150 ml of ethyl acetate
  3. washThe organic solution is washed first with 50 ml of an aqueous solution of sodium bicarbonate

Sources & evidence

ORD record
ord-77a61adbb99741d4b65194677054727a
Source dataset
uspto-grants-1981_01
Patent number
US04247551

Reaction notes

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