Diethyl Ether → 6-N-(2,5-Dimethylpyrrol-1-yl)-3-N,3-N-dimethylpyridazine-3,6-diamine

HRID 1390008Notes

Reaction equation

HRID 1390008 reaction equation
Cl.Cl.[NH:3]([C:5]1[N:6]=[N:7][C:8]([N:11]([CH3:13])[CH3:12])=[CH:9][CH:10]=1)[NH2:4].[CH3:14][C:15](=O)[CH2:16][CH2:17][C:18](=O)[CH3:19].C([O-])(=O)C.[Na+].C(OCC)C>C(O)(=O)C>[CH3:19][C:18]1[N:4]([NH:3][C:5]2[N:6]=[N:7][C:8]([N:11]([CH3:13])[CH3:12])=[CH:9][CH:10]=2)[C:15]([CH3:14])=[CH:16][CH:17]=1

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 80352,5-HexanedioneHCID 517045Sodium AcetateHCID 30439483(2H)-Pyridazinone, 6-(dimethylamino)-, hydrazone, dihydrochloride

Product 1

HCID 232744906-N-(2,5-Dimethylpyrrol-1-yl)-3-N,3-N-dimethylpyridazine-3,6-diamineYield 47%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The product is obtained according to the procedure of example 19 by reacting 3-hydrazino-6-dimethylamino-pyridazine dihydrochloride and 2,5-hexanedione in acetic acid in the presence of sodium acetate. Yield 47%; m.p. 165°-167° C. (from ethyl ether).

Workup

  1. customThe product is obtained

Sources & evidence

ORD record
ord-d8fcb31f34e04b869b486e802529bd47
Source dataset
uspto-grants-1981_01
Patent number
US04247551

Reaction notes

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