Sulfuric Acid → 4-[(iodomethyl)sulfonyl]aniline

Participants

Reaction Steps

A mixture of 63.7 g. of N-[p-(iodomethylsulfonyl)-phenyl]acetamide and 360 ml. of 5.5 N sulfuric acid is stirred and heated at reflux until all of the solid dissolves. After cooling, the crude, solid product separates; it is collected, washed with cold water and air-dried. After crystallization from methanol, 26 g. of p-(iodomethylsulfonyl)aniline is obtained; m.p. 169.5°-72° C.

Provenance & Evidence