Benzenesulfonyl chloride → HCID 20294478, compound

Participants

Reaction Steps

4-Chloro-3-hydroxy-5-methylisoxazole was reacted with benzenesulphonyl chloride in the presence of triethylamine to give 3-benzenesulphonyloxy-4-chloro-5-methylisoxasole, which was then reacted with N-bromosuccinimide to give 3-benzenesulphonyloxy-5-bromomethyl-4-chloroisoxazole. This was then treated by the procedure described in Preparation 10, to afford benzhydryl 4-chloro-3-hydroxyisoxazol-5-ylmethylthioacetate.

Provenance & Evidence