反应详情

To a stirred solution of 3-n-butylamino-4-phenoxy-5-sulfamylbenzylamine (1.05 g; prepared as described in Example 289) in pyridine (7 ml) ethyl chloroformate (0.3 ml) is dropwise added at 22°-25° C., and the mixture is stirred for a further 1.5 hours. The mixture is then diluted with water (30 ml) and acetic acid (10 ml) to precipitate crude N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)urethan. After filtration and recrystallization from ethanol it is obtained with a melting point of 105°-107° C.

1. customto precipitate crude N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)urethan
2. filtrationAfter filtration and recrystallization from ethanol it
3. customis obtained with a melting point of 105°-107° C.