反应详情

To a solution of 4.8 g. of 5-amino-1-naphthol in 210 ml. of acetonitrile were added 2.5 ml. of pyridine and a mixture of 75 ml. of acetonitrile and 5.6 g. of morpholinosulfonyl chloride was added dropwise thereto under stirring and ice-cooling. Stirring was continued at room temperature for 2 hours and reaction was conducted at 40° C. for 1 hour. The mixture was concentrated and the residue was added to about 150 ml. of water containing 3 ml. of conc. hydrochloric acid. The precipitate thus separated was recovered by filtration, washed with water and then dried to give 6.7 g. of the desired product with m.p. 220°-223° C. (with dec.).

1. temperatureice-cooling
2. stirringStirring
3. customreaction
4. waitwas conducted at 40° C. for 1 hour
5. concentrationThe mixture was concentrated
6. additionthe residue was added to about 150 ml
7. customThe precipitate thus separated
8. filtrationwas recovered by filtration
9. washwashed with water
10. customdried
11. customto give 6.7 g