5-Nitroso-2,4,6-pyrimidinetriamine → tetra-Aminopyrimidine

HRID 1390098Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1390098
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:12]=[C:11]([NH2:13])[C:10]([NH2:14])=[C:9]([NH2:15])[N:8]=1.N(C1C(N)=NC(N)=NC=1N)=O>O.[Zn]>[NH2:6][C:7]1[N:12]=[C:11]([NH2:13])[C:10]([NH2:14])=[C:9]([NH2:15])[N:8]=1

Komponenten

5

Edukt 2

HCID 705045-Nitroso-2,4,6-pyrimidinetriamineHCID 79358Tetraaminopyrimidine sulfate

Produkt 1

HCID 70487tetra-Aminopyrimidine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 962WaterLösungsmittel

Versuchsvorschrift

In accordance with the present invention, a process for preparing 2,4,5,6-tetraaminopyrimidine sulfate (TAPS) comprises (1) reacting about one molecular proportion of 5-nitroso-2,4,6-triaminopyrimidine (NTAP) in water with about 2.0 to 2.5 molecular proportions of zinc dust and about 4.0 to 4.7 molecular proportions of a suitable acid, to provide a reaction mixture having a pH below 7; (2) reacting the reaction mixture at a temperature of about 20° to 65° C. to form the acid salt of 2,4,5,6-tetraaminopyrimidine; (3) adjusting the pH to about 2.0 to 2.5 by adding the suitable acid to form a solution of the acid salt; (4) separating the insoluble materials from step (3) to obtain a wet cake and a mother liquor; (5) adding sulfuric acid to the mother liquor to adjust the pH to about 0.2 to 0.5 while maintaining the temperature at about 20° to 60° C.; (6) cooling the reaction mixture of step (5) to about 0° to 10° C. to precipitate 2,4,5,6-tetraaminopyrimidine sulfate; and (7) recovering the precipitate.

Aufarbeitung

  1. customabout 4.0 to 4.7 molecular proportions of a suitable acid, to provide a reaction mixture
  2. customat a temperature of about 20° to 65° C.

Quellen und Nachweise

ORD-Eintrag
ord-30ebe879d659453096ec7b3a657384af
Quelldatensatz
uspto-grants-1981_01
Patentnummer
US04247693

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