5-Nitroso-2,4,6-pyrimidinetriamine → tetra-Aminopyrimidine

Participants

Reaction Steps

A process for preparing 2,4,5,6-tetraaminopyrimidine sulfate (TAPS) comprising (1) reacting about one molecular proportion of 5-nitroso-2,4,6-triaminopyrimidine (NTAP) in water with about 2.0 to 2.5 molecular proportions of zinc dust and about 4.0 to 4.7 molecular proportions of a suitable acid to provide a reaction mixture having a pH below 7; (2) reacting said reaction mixture at a temperature of about 20° to 65° C. to form the acid salt of 2,4,5,6-tetraaminopyrimidine; (3) adjusting the pH to about 2.0 to 2.5 by adding said acid to form a solution of said salt; (4) separating the insoluble materials from step (3) to obtain a wet cake and a mother liquor; (5) adding sulfuric acid to said mother liquor to adjust the pH to about 0.2 to 0.5 while maintaining the temperature at about 20° to 60° C.; (6) cooling the reaction mixture of step (5) to about 0° to 10° C. the precipitate 2,4,5,6-tetraaminopyrimidine sulfate; and (7) recovering said precipitate.

Provenance & Evidence