HCID 12952944, compound → HCID 12952946, compound

HRID 1390133Notes

Reaction equation

HRID 1390133 reaction equation
O.[ClH:2].Cl.C([N:11](CC1C=CC=CC=1)[CH2:12][CH2:13][CH:14]1[CH2:18][N:17]([CH2:19][CH3:20])[C:16](=[NH:21])[N:15]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[ClH:2].[ClH:2].[NH2:11][CH2:12][CH2:13][CH:14]1[CH2:18][N:17]([CH2:19][CH3:20])[C:16](=[NH:21])[N:15]1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 2

HCID 12952944HCID 12952944, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12952946HCID 12952946, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 10.0 g (0.023 mole) of 4-(2-dibenzylaminoethyl)-1-ethyl-2-imino-3-phenylimidazolidine dihydrochloride hydrate in 175 ml of ethanol was shaken for 7 hours in a Parr apparatus at 70° C. with palladium catalyst at 45 p.s.i. hydrogen. After filtering and concentrating the filtrate in vacuo, the solid residue was recrystallized from a 80/20% mixture of isopropanol-ethanol. The salt weighed 4.55 g (70% yield); m.p. 223°-224° C.

Workup

  1. filtrationAfter filtering
  2. concentrationconcentrating the filtrate in vacuo
  3. customthe solid residue was recrystallized from a 80/20% mixture of isopropanol-ethanol

Sources & evidence

ORD record
ord-5514f584d192469eb2f1376df5e666ce
Source dataset
uspto-grants-1981_01
Patent number
US04247705

Reaction notes

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