Sodium Hydroxide → HCID 12774099, compound

HRID 1390139Notes

Reaction equation

HRID 1390139 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)(CC#C[Si](C)(C)C)[C:8]2=[O:12])=[CH:4][C:3]=1[O:27][CH2:28][C:29]([O:31]CC)=[O:30].[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][CH:7]([C:20]3[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=3)[C:8]2=[O:12])=[CH:4][C:3]=1[O:27][CH2:28][C:29]([OH:31])=[O:30]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13065299HCID 13065299, compound

Product 1

HCID 12774099HCID 12774099, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

- Desilylation and hydrolysis of ethyl [6,7-dichloro-1-oxo-2-(p-fluorophenyl)-2-(3-(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate with sodium hydroxide in ethanol according to the procedure of Example 1, STEP (c), affords the title compound, m.p. 189°-190°.

Sources & evidence

ORD record
ord-334e2fcc4a8b4d3880d1b84e734fce9d
Source dataset
uspto-grants-1981_01
Patent number
US04247715

Reaction notes

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