Sodium Hydroxide → (6,7-Dibromo-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic Acid

HRID 1390140Notes

Reaction equation

HRID 1390140 reaction equation
[Br:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)([CH2:13][C:14]#[C:15][Si](C)(C)C)[C:8]2=[O:12])=[CH:4][C:3]=1[O:26][CH2:27][C:28]([O:30]CC)=[O:29].[OH-].[Na+]>C(O)C>[Br:1][C:2]1[C:10]([Br:11])=[C:9]2[C:5]([CH2:6][C:7]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)([CH2:13][C:14]#[CH:15])[C:8]2=[O:12])=[CH:4][C:3]=1[O:26][CH2:27][C:28]([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13065300HCID 13065300, compound

Product 1

HCID 13065302(6,7-Dibromo-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic Acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

- Desilylation and hydrolysis of ethyl [6,7-dibromo-1-oxo-2-phenyl-2-(3(trimethylsilyl)-2-propynyl)-5-indanyloxy]acetate with sodium hydroxide in ethanol according to the procedure of Example 1, STEP (c), affords the title compound.

Sources & evidence

ORD record
ord-e696da04a14048b780c3f1b41d92be6e
Source dataset
uspto-grants-1981_01
Patent number
US04247715

Reaction notes

Loading…