Hydrochloric Acid → 4-Chloro-2-fluoroaniline

Participants

Reaction Steps

4'-Chloro-2'-fluoroacetanilide is refluxed in a mixture of a lower alcohol (50%) (e.g. ethanol) and concentrated hydrochloric acid (50%) for several hours (e.g. 5 or more) at 70°-90° C. and atmospheric pressure. The solvent mixture is removed at a reduced pressure of 100 to 300 mm.Hg and 20°-50° C. to leave a residue of the hydrochloride salt of 4-chloro-2-fluoroaniline.

Provenance & Evidence