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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1390210Generated: October 26, 2026

N-(2-Hydroxyethyl)ethylenediamine → Mitoxantrone Impurity 2

https://huagongshe.com/reaction/1390210

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-Hydroxyethyl)ethylenediamineHCID 8112—
Reactant9,10-Anthracenedione, 2,3-dihydro-1,4,5,8-tetrahydroxy-HCID 66485—
ProductMitoxantrone Impurity 2HCID 22748598—

Reaction Steps

The reaction between 2-(2-hydroxyethylamino)ethylamine and leuco-1,4,5,8-tetrahydroxyanthraquinone is carried out as in Example 1 to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04138415
Source datasetuspto-grants-1979_02
ORD IDord-e915004d62dd4f3381b5b89bf83c8938
Source noteuspto-grants-1979_02