Diethylamine → [(Diethylcarbamoyl)methyl]phosphonic acid

HRID 1390248ノート

反応式

HRID 1390248 の反応式
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].[C:6]([CH2:9][P:10](=[O:15])([O:13]C)[O:11]C)(O)=[O:7].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH2:1]([N:3]([CH2:4][CH3:5])[C:6]([CH2:9][P:10](=[O:15])([OH:13])[OH:11])=[O:7])[CH3:2]

参加物

5

反応物 3

HCID 8021DiethylamineHCID 10868DicyclohexylcarbodiimideHCID 1899642-(Dimethoxyphosphoryl)acetic acid

生成物 1

HCID 18756985[(Diethylcarbamoyl)methyl]phosphonic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Diethylamine (0.045 mole) and dimethyl (carboxymethyl)phosphonate (0.04 mole) were dissolved in 100 ml. of methylene chloride. As the solution was stirred, dicyclohexylcarbodiimide was added portionwise. The solution was stirred overnight and the mixture was filtered. The filtrate was concentrated to a solid. It was recrystallized from an appropriate solvent such as methanol.

後処理

  1. stirringThe solution was stirred overnight
  2. filtrationthe mixture was filtered
  3. concentrationThe filtrate was concentrated to a solid
  4. customIt was recrystallized from an appropriate solvent such as methanol

出典と根拠

ORDレコード
ord-71060c5beb534158a207171f6137d70e
出典データセット
uspto-grants-1979_02
特許番号
US04138432

反応ノート

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