HCID 90474469, compound → HCID 178446025, compound

HRID 1390259Notes

Reaction equation

[NH:1]([C:49](OC(C)(C)C)=[O:50])[C@H:2]([C:7]([NH:9][C@H:10]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@H:19]([C:25]([NH:27][C@@H:28]([C:39]([O:41][CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=[O:40])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:38])[NH:34][N+:35]([O-:37])=[O:36])=[O:26])[CH2:20][CH2:21][C:22](=[O:24])[NH2:23])=[O:17])=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[N:56]1([C:77]2[CH:88]=[CH:87][C:83]([N+:84]([O-:86])=[O:85])=[CH:82][C:78]=2[N+:79]([O-:81])=[O:80])[CH2:76][CH2:75][CH2:74][C@H:57]1C(N[C@H](C(NCC(O)=O)=O)CCC(=O)N)=O>>[N:56]1([C:77]2[CH:88]=[CH:87][C:83]([N+:84]([O-:86])=[O:85])=[CH:82][C:78]=2[N+:79]([O-:81])=[O:80])[CH2:76][CH2:75][CH2:74][C@H:57]1[C:16]([NH:18][C@H:19]([C:25]([NH:27][CH2:28][C:49]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:12]([NH:14][CH2:15][C:16]([NH:18][C@H:19]([C:25]([NH:27][C@@H:28]([C:39]([O:41][CH2:42][C:43]1[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1)=[O:40])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:38])[NH:34][N+:35]([O-:37])=[O:36])=[O:26])[CH2:20][CH2:21][C:22](=[O:24])[NH2:23])=[O:17])=[O:13])[CH3:11])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5])=[O:50])=[O:26])[CH2:20][CH2:21][C:22](=[O:24])[NH2:23])=[O:17]

Participants

Reactant 2

HCID 90474469HCID 90474469, compound

HCID 178446052HCID 178446052, compound

Product 1

HCID 178446025HCID 178446025, compound

Procedure

Boc-Leu-Ala-Gly-Gln-D-Arg(NO2)-OBzl (350 mg, 0.45 m mol) was demasked with respect to the N-masking group and coupled with DNP-Pro-Gln-Gly-OH (210 mg, 0.45 m mol) in the manner similar to that of Example 1, paragraph 7).

Sources & evidence

ORD record: ord-86513043c6e94ff880b19aa16698ee16
Source dataset: uspto-grants-1979_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04138394

Reaction notes

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