L-Phenylalanine → HCID 22806795, compound

Participants

Reaction Steps

8.3 G (0.05 mol) of L-phenylalanine and 13.9 ml (0.1 mol) of triethylamine were dissolved in 50 ml of water. To the solution was added 100 ml of dioxane solution containing 8.6 g (0.5 mol) of 4-nitrobenzylchloride. 3.0 g (0.05 mol) of carbonyl sulfide was blown into the solution at a temperature of from 10° to 15° C. in 15 minutes. After completion of blowing, the mixture was subjected to reaction at room temperature for 2 hours. After completion of reaction, the solid material obtained in a similar manner to that described in Example 1 was recrystallized from 50 ml of ethylacetate and 20 ml of n-hexane to yield 9.4 g of pale yellow crystals.

Provenance & Evidence