Triethylamine → HCID 53782825, compound

Participants

Reaction Steps

10.8 G (0.05 mol) of L-phenylalanine methylester hydrochloride was added to 100 ml of chloroform. To the mixture was added 13.9 ml (0.1 mol) of triethylamine while cooling with ice. 20 Ml of a chloroform solution containing 3.0 g (0.05 mol) of carbonyl sulfide was dropwise added to the solution at a temperature of from 5° to 10° C. in 20 minutes. After stirring at the same temperature for 30 minutes, 30 ml of chloroform solution containing 7.7 g (0.05 mol) of 2.5-dimethylbenzylchloride was dropwise added to the solution in 30 minutes. After this, the mixture was stirred at room temperature for 1 hour. After completion of reaction, the reaction mixture was washed with 100 ml of water, 100 ml of 2N-hydrochloric acid and 150 ml of water in order twice and was dried over anhydrous sodium sulfate in a similar manner to that described in Example 2. After filtration of the drying agent, the syrup-like substance obtained by removing the solvent of the filtrate in vacuo was crystallized from 30 ml of ethylacetate and 50 ml of n-hexane to yield 10.8 g of white crystals.

Provenance & Evidence