Water → HCID 86736290, compound

HRID 1390277Notes

Reaction equation

HRID 1390277 reaction equation
[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][C:7]([NH:9][C@H:10]([C:18]([OH:20])=[O:19])[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[S:8])=[CH:4][CH:3]=1.O.[OH-].[Na+:25]>CC(C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]([NH:9][C@H:10]([C:18]([O-:20])=[O:19])[CH2:11][C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[S:8])=[CH:21][CH:22]=1.[Na+:25]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 54152741HCID 54152741, compound

Product 1

HCID 86736290HCID 86736290, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3.6 G (0.011 mol) of N-(4-methylbenzylthiocarbonyl)-L-phenylalanine was dissolved in 10 ml of acetone. To the mixture were added 30 ml of water and 10 ml of 1N-sodium hydroxide and then the mixture was stirred at room temperature for 1 to 2 minutes to obtain a transparent solution. After the solution was washed with 30 ml of ether twice, the water layer was evaporated under reduced pressure. To remove the remaining amounts of water from the residue, a small quantity of ethanol was added to the residue and then evaporated under reduced pressure. This operation was repeated three times. Thus, the residue was completely dried to obtain 3.4 g of white powder of the desired sodium salt.

Workup

  1. customto obtain a transparent solution
  2. washAfter the solution was washed with 30 ml of ether twice
  3. customthe water layer was evaporated under reduced pressure
  4. customTo remove the remaining amounts of water from the residue
  5. additiona small quantity of ethanol was added to the residue
  6. customevaporated under reduced pressure
  7. customThus, the residue was completely dried

Sources & evidence

ORD record
ord-b29d275eb7404407bc420e6deaf1c9c4
Source dataset
uspto-grants-1979_02
Patent number
US04138485

Reaction notes

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