2-Pyrrolidone → N-(m-Trifluoromethylphenyl)-3-methylthio-4-chloromethyl-2pyrrolidone

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Reaction Steps

In the same manner as descried above for Example 1, sodium methyl mercaptide prepared from 6.5 g of a 25% methanol solution of sodium methoxide in 50 ml of dimethylformamide was added to 9.4 g (0.034 mole) of N-(m-trifluoromethylphenyl)-3-chloro-4-chloromethyl-2-pyrrolidone (prepared according to the procedure described in U.S. Pat. No. 4,069,038). The product weighed 9.3 g, representing 85% yield based on the pyrrolidone, structure confirmed by NMR analysis, with refractive index nD30 =1.5028. This compound is shown in Table I as Compound No. 2.

Provenance & Evidence