反应详情

To a mixture of 92.1 g (0.5 mole) of benzhydrol and 142.7 g. (1.5 mole) of 2-hydroxypyridine heated at 180°, add with stirring 1.5 ml. of concentrated sulfuric acid. Heat the mixture at 250°-255° for 2 hours with the removal of water. Pour the cooled reaction mixture into water, stir, and extract with chloroform. Concentrate the chloroform extracts to a residue containing 5-(diphenylmethyl)-2-pyridone. Triturate the residue with ethyl acetate and filter the solids to obtain 5-(diphenylmethyl)-2-pyridone plus other isomers. Recrystallize from acetonitrile to obtain the product of this example, m.p. 174°-176° C.

1. additionadd
2. temperatureHeat the mixture at 250°-255° for 2 hours
3. customwith the removal of water
4. additionPour
5. customthe cooled reaction mixture into water
6. stirringstir
7. extractionextract with chloroform
8. concentrationConcentrate the chloroform
9. additioncontaining 5-(diphenylmethyl)-2-pyridone
10. customTriturate the residue with ethyl acetate
11. filtrationfilter the solids