Phenylphosphonic dichloride → 2-Chloro-5-(4-Chlorophenyl-Phenylmethyl)-Pyridine

참여 물질

반응 단계

Combine 50 g. (0.174 mole) of the 5-substituted 2-pyridone from step A with 125 ml. of phenylphosphonic dichloride and heat at 210°-220° C. for about 7 hours with stirring. Allow to stand overnight and pour onto ice. Basify with ammonium hydroxide and extract with ethyl ether. Dry the ether solution and concentrate to a residue. Distill the residue and collect the fraction boiling at 205°-215° C. at 0.55 mm. (49 g.).

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