2,4-Dimethylpyridine → 2-Chloro-5-[Bis-(4-Chlorophenyl)-Methyl]-Pyridine

Participants

Reaction Conditions

Reaction Steps

To a mixture of 35.2 g. (0.11 mole) of 5-[bis-(4-chlorophenyl)-methyl]-2-pyridone and 11.8 g. (0.11 mole) of 2,4-lutidine, add 50.6 g. (0.33 mole) of phosphorous oxychloride (dropwise) while heating the reaction mixture at 80°. Then, heat the reaction mixture at 120° C. for six hours. Pour the reaction mixture onto ice, basify with ammonium hydroxide, extract with benzene and remove both the benzene and residual 2,4-lutidine by distillation. Distill the residue at about 195°-210° C. (0.01 mm) to obtain thereby about 30 g. of the product of this step as a yellow viscous oil.

Provenance & Evidence