HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ribavirin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 2,3-o-Isopropylidene-l-ribofuranose | HCID 547777 | — |
| Reactant | HCID 178511376 | HCID 178511376 | — |
| Product | Ribavirin | HCID 37542 | — |
Reaction Steps
In a preferred method of synthesis as shown in Scheme I, cyanoformimidic acid hydrazide is reacted with 2,3-O-isopropylidene-D-ribose to yield N1 -(2,3-O-isopropylidene-D-ribofuranosyl)cyanoformamidrazone which is ring closed with triethylorthoformate followed by treatment with ammonia and acid hydrolysis of the isopropylidene group to yield 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. ##STR1##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04138547 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-2896856f891740ada14e97c2e8f005ea |
| Source note | uspto-grants-1979_02 |