HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-(6-Fluoro-3-nitro-2-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Difluoro-3-nitropyridine | HCID 11389546 | — |
| Reactant | 4-((Benzyloxy)carbonyl)piperazine-2-carboxylic acid hydrochloride | HCID 45072677 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-(6-Fluoro-3-nitro-2-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid | HCID 23339770 | — |
Reaction Steps
In a similar procedure to that described in Example 1, from 6.0 g. of 2,6-difluoro-3-nitropyridine, 9.0 g. of 4-carbobenzoxypiperazine-2-carboxylic acid, hydrochloride, 20 ml. of triethylamine and 150 ml. of dimethyl sulfoxide, there is obtained 14 g. of the title product as a viscous orange glass. Thin layer chromatographic analysis of this material shows essentially one spot.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04138564 |
| Source dataset | uspto-grants-1979_02 |
| ORD ID | ord-8373faa71e384406b5b29080949c6c89 |
| Source note | uspto-grants-1979_02 |