反应详情

A mixture of 1.5 g. of 8-carbobenzoxy-7,8,9,10-tetrahydro-5H-pyrazino[1,2-a]pyrido[3,2-e]pyrazin-6(6aH)-one, 1 g. of 10% palladium on carbon, and 150 ml. of ethanol is hydrogenated at 45 psi for 2 hours. The catalyst is filtered and the filtrate is concentrated. The residue is dissolved in a small amount of ethanol and ethanolic hydrogen chloride is added. Filtration of the precipitated salt gives 0.72 g. of the title product, m.p. 270° dec. Recrystallization from ethanol-water gives 0.60 g., m.p. 278°-279°.

1. additionA mixture of 1.5 g
2. filtrationThe catalyst is filtered
3. concentrationthe filtrate is concentrated
4. dissolutionThe residue is dissolved in a small amount of ethanol and ethanolic hydrogen chloride
5. additionis added
6. filtrationFiltration of the precipitated salt
7. customgives 0.72 g