3-Hydroxy-2-(phenylamino)-4-(phenylimino)-2-cyclobuten-1-one → 1-[2-Hydroxy-3-(cis-3,5-dimethyl-4-propyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-cis-3,5-dimethyl-4-propylpiperazinium hydroxide

Participants

Reaction Steps

A mixture of 1.5 grams of 2-anilino-3-hydroxy-4-(phenylimino)-2-cyclobuten-1-one and 1.9 grams of cis-2,6-dimethyl-1-propylpiperazine is heated at 216°-218° C. for 15 minutes under an atmosphere of dry nitrogen. The product is then isolated as described in Example 5 to give 1-[2-hydroxy-3-(cis-3,5-dimethyl-4-propyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-cis-3,5-dimethyl-4-propylpiperazinium hydroxide inner salt as a pale pinkish brown microcrystalline solid melting at about 202°-204° C.

Provenance & Evidence