3-Hydroxy-2-(phenylamino)-4-(phenylimino)-2-cyclobuten-1-one → 1-[2-Hydroxy-3-(cis-2,6-dimethyl-4-propyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-cis-2,6-dimethyl-4-propylpiperazinium hydroxide

Participants

Reaction Steps

A mixture of 0.48 grams of 2-anilino-3-hydroxy-4-(phenylimino)-2-cyclobuten-1-one and 0.63 grams of cis-3,5-dimethyl-1-propylpiperazine is heated at 230°-240° C. for 10 minutes. The product is then isolated from the reaction mixture according to the procedure described in Example 5 to give 1-[2-hydroxy-3-(cis-2,6-dimethyl-4-propyl-1-piperazinyl)-4-oxo-2-cyclobuten-1-ylidene]-cis-2,6-dimethyl-4-propylpiperazinium hydroxide inner salt melting at about 218°-227° C. This compound has the following formula ##STR3##

Provenance & Evidence