Ethanol → Clobazam

Participants

Reaction Steps

Starting from 1-phenyl 8-chloro 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine(obtained according to the example XI) and from a halide, and operating according to the example X, there is obtained 1-phenyl 5-methyl 8-chloro 1,2,4,5-tetrahydo 2,4-dioxo 3H-1,5-benzodiazepine, melting at 166°-168° C. after recristallisation in 50% ethanol.

Provenance & Evidence