Trichloroacetyl isocyanate → HCID 131710430, compound

Participants

Reaction Steps

Trichloroacetyl isocyanate (13.2 g, 70 mmole) was added to a stirred suspension of diphenylmethyl (6R,7R)-3-hydroxymethyl-7-(thien-2-ylacetamido)ceph-3-em-4 carboxylate (26.0 g, 50 mmole) in anhydrous acetone (600 ml) at 20°. The solid soon dissolved and after the mixture had been stirred at 20° for 1 hour it was chilled for 1 hour and the resulting solid was filtered off and washed with ether to give the title compound (33.1 g, 93%), m.p. 183° to 184°; [α]D21 + 24° (c 0.95 in DMSO); λinf.EtOH 235 nm (ε 14,500) and λinf.EtOH 256 nm (ε 8,820).

Provenance & Evidence