HCID 12295055, compound → HCID 12295104, compound

Participants

Reaction Steps

By catalytic hydrogenation of 12.0 g of 3,4-bis(p-anisoyloxy)phenyl tert-butylaminomethyl ketone hydrochloride in 300 ml.of anhydrous ethyl alcohol in the presence of 2.0 g. of 10 percent palladium-on-charcoal catalyst there was obtained 6.2 g of 3,4-bis(p-anisoyloxy)-alpha-(tert-butylaminomethyl)benzyl alcohol hydrochloride as a white crystalline solid which melted at 165° C. (uncorr.). The solubility of this salt in polyethyleneglycol 200 at 25° C. was less than 1 percent. When 1 percent solutions of this salt in each of dimethyl sulfoxide and glycerol formal were diluted with three volumes of water, no precipitate formed.

Provenance & Evidence