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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1390491Generated: October 25, 2026

2-Chloro-4-(chlorosulfonyl)benzoic acid → rel-2-Chloro-5-(((3R,5S)-3,5-dimethyl-1-piperidinyl)sulfonyl)benzoic acid

https://huagongshe.com/reaction/1390491

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-(chlorosulfonyl)benzoic acidHCID 188427—
Reactant2-Chloro-4-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acidHCID 54444559—
Productrel-2-Chloro-5-(((3R,5S)-3,5-dimethyl-1-piperidinyl)sulfonyl)benzoic acidHCID 32335—

Reaction Steps

In the same way, 2-chloro-4-(cis-3,5-dimethylpiperidinosulfonyl)benzoic acid, m.p. 233°-234° C., is prepared from 2-chloro-4-chlorosulfonylbenzoic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04138399
Source datasetuspto-grants-1979_02
ORD IDord-8d5886b06fdb43a59cbf84e90335235f
Source noteuspto-grants-1979_02