Thionyl Chloride → HCID 20505854, compound

HRID 1390506Notes

Reaction equation

HRID 1390506 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:19][CH:18]([CH3:20])[CH2:17][CH:16]([CH3:21])[CH2:15]2)(=[O:13])=[O:12])=[CH:7][C:3]=1[C:4]([Cl:24])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 30158922-Chloro-5-(3,5-dimethylpiperidinosulphonyl)benzoic acid

Product 1

HCID 20505854HCID 20505854, compound

Procedure

2-Chloro-5-(3,5-dimethylpiperidinosulfonyl)benzoic acid (6.0 g.) is refluxed for 21/2 hours with 50 ml. of thionyl chloride, and then taken to dryness. The residue is triturated with 200 ml. of hot benzene-hexane (1:1), filtered and evaporated to obtain the dry product, m.p. 164°-166.5° C.

Workup

  1. customThe residue is triturated with 200 ml
  2. filtrationof hot benzene-hexane (1:1), filtered
  3. customevaporated
  4. customto obtain the dry product, m.p. 164°-166.5° C.

Sources & evidence

ORD record
ord-01070e7ea15046ebbfa70290b358f7a8
Source dataset
uspto-grants-1979_02
Patent number
US04138399

Reaction notes

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