Thionyl Chloride → HCID 20380993, compound

Participants

Reaction Steps

1.5 ml (10 mMole) of thionyl chloride are slowly added dropwise at 0° to +5° C to 1.04 g (5 mMole) of 4-hydroxymethyl-5-methyl-5-phenyl oxazolidin-2-one dissolved in 15 ml of pyridine. After 1 hour at 50° C, the reaction solution is stirred overnight at room temperature, poured onto ice and repeatedly extracted with chloroform. The combined chloroform phases dried over Na2SO4 are concentrated. The crystals formed are recrystallised from methanol.

Provenance & Evidence